Resolution:
## Figure 7.
Growth rate of sensitive cell as a function of P-gp content. A, computer simulation giving the number of sensitive MCF-7 versus time during a chemotherapy regimen, cycling every 14 days, with 10 days of 1 μM doxorubicin
treatment followed by 4 days of interruption, for 4 cycles. The initial simulated
tumour consisted in 10^{4 }MCF-7 having growth rates corresponding to ρ(p_{min}). B, plot giving the growth rates ρ as a function of the P-gp-driven calceinAM efflux
activity p for cells exposed to 1 μM doxorubicin. The function describing ρ(p) is used in the simulations presented Figure 8. All cells having a negative growth
rate are considered as sensitive MCF-7.
Pasquier |