Biology Direct serves the life science research community as an open access, peer-reviewed online journal, providing authors and readers with an alternative to the traditional model of peer review. Biology Direct considers original research articles, hypotheses, comments, discovery notes and reviews in subject areas currently identified as those most conducive to the open review approach, primarily those with a significant non-experimental component.
- Eugene Koonin, NCBI, NLM, NIH
- Laura Landweber, Princeton University
- David Lipman, NCBI, NLM, NIH
ResearchThe stringent homology-based prediction approach takes into account (i) differences between eukaryotic and prokaryotic proteins and (ii) differences between inter-species and intra-species PPI interfaces. Therefore it has better performance and resolves limitations of conventional eukaryote-prokaryote inter-species PPIs prediction (which uses intra-species template PPIs).
ReviewThe study analyzes nine motif finding Web tools for detecting binding site motifs in ChIP-Seq data. The detailed features of each tool, its approach, as well as its strengths and weaknesses are discussed.
Based on a regression analysis which includes measurement errors and confidence intervals, genome size-time data for major phyla are found to be consistent with life having originated after Earth's formation.
The loss of information through the multiple processing steps of biological systems may explain the common scaling relations between inputs and outputs.
One of the major challenges in designing epitope or peptide-based vaccine is to induce desired interleukin, particularly induction of interferon-gamma is important for designing vaccine against intracellular pathogens.
The highly similar eukaryotic translation elongation factors 1A1 and
1A2 show a surprising enhancement of post-translational modification proximal to surface clusters of sequence variation on their modelled structures informing on their functional divergence.
Drug discovery is a costly and time consuming process that can be improve significantly with the help of software drugmint developed for predicting drug like molecules.
Unique model of peer review
Biology Direct offers a novel system of peer review, allowing authors to select suitable reviewers from the journal's Editorial Board; making the peer-review process open rather than anonymous; and making the reviewers' reports public, thus increasing the responsibility of the referees and eliminating sources of abuse in the refereeing process.
Biology Direct publishes in the following sections:
- Evolutionary Biology
- Mathematical Biology
- Non-coding DNA & RNA
- Structural & Molecular biology
- Systems Biology
For details of Section Editors and Editorial Board members, please see the Editorial Board page.
Edited by Dr Maureen O'Malley and Dr Yan Boucher
Published: 30 June 2011
Edited by Prof Marek Kimmel
Published: 20 April 2010
Edited by Dr Eugene Koonin
Published: 24 April 2009
Edited by Dr Eugene Koonin
Published: 9 July 2008
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