Biology Direct serves the life science research community as an open access, peer-reviewed online journal, providing authors and readers with an alternative to the traditional model of peer review. Biology Direct considers original research articles, hypotheses, comments, discovery notes and reviews in subject areas currently identified as those most conducive to the open review approach, primarily those with a significant non-experimental component.
- Eugene Koonin, NCBI, NLM, NIH
- Laura Landweber, Princeton University
- David Lipman, NCBI, NLM, NIH
ResearchThe N-degron recognizing UBR-box has likely evolved from a RING-like treble clef zinc finger scaffold via circular permutation.
ResearchIntrons are widespread in 16S rRNA genes of (hyper)thermophilic Thermoproteales (phylum Crenarchaeota) and their presence interferes with the use of “universal” primers often used in environmental gene surveys.
ReviewPhysicochemical principles frame the natural emergence of life in terms of the chemical evolution of molecules and macromolecules in mixed electrolytes undergoing cyclic phase transitions in confined microspaces under crowded conditions.
ResearchThe human transmembrane proteome database (HTP database) includes an accurate, consensus constrained topology prediction for each human alpha-helical transmembrane protein, incorporating recent state of the art methods, as well as all available structural, experimental and computational topology data.
ResearchA physico-chemically plausible model of the RNA World scenario proving that RNA replicators bound to clay minerals and catalyzing the production of their own monomers may have booted up life.
ResearchA combination of protein docking, molecular dynamics simulations and sequence analysis identifies amino acid residues of apoptotic protease activating factor 1 that bind cytochrome c upon apoptosome assembly.
Discovery notesAlthough imprecise intron losses cause indels in coding sequences, they comprise an appreciable proportion of the fixed intron losses in Solanum and Arabidopsis.
Unique model of peer review
Biology Direct offers a novel system of peer review, allowing authors to select suitable reviewers from the journal's Editorial Board; making the peer-review process open rather than anonymous; and making the reviewers' reports public, thus increasing the responsibility of the referees and eliminating sources of abuse in the refereeing process.
Biology Direct publishes in the following sections:
- Evolutionary Biology
- Mathematical Biology
- Non-coding DNA & RNA
- Structural & Molecular biology
- Systems Biology
For details of Section Editors and Editorial Board members, please see the Editorial Board page.
Edited by Dr Maureen O'Malley and Dr Yan Boucher
Published: 30 June 2011
Edited by Prof Marek Kimmel
Published: 20 April 2010
Edited by Dr Eugene Koonin
Published: 24 April 2009
Edited by Dr Eugene Koonin
Published: 9 July 2008
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